Last year, PBS News10
 reported that 1,500 deaths over the past 10 years have been linked to 
taking a little bit more acetaminophen than the recommended dosage. A 
major problem, as PBS points out, is that while acetaminophen is 
considered safe when taken as recommended, the margin between a safe dose and a potentially lethal one is disturbingly small. According to their report:
"Taken over several days, as little as 25 percent above 
the maximum daily dose - or just two additional extra strength pills a 
day - has been reported to cause liver damage, according to the [Food and Drug Administration]. Taken all at once, a little less than four times the maximum daily dose can cause death...
Warnings on liver damage were added to the drug's label in 2009 
by the FDA, 32 years after an expert panel convened by the agency 
advised it was 'obligatory' to do so. The recommendation was a part of a
 broader safety review of acetaminophen, which the report says has not 
yet been completed." [Emphasis mine]
An FDA advisory panel actually recommended adding a warning label 
about liver damage to acetaminophen as early as 1977, yet the FDA kept 
dragging its feet.